Targeting of Slc25a21 Is Associated with Orofacial Defects and Otitis Media Due to Disrupted Expression of a Neighbouring Gene

Homozygosity for Slc25a21(tm1a(KOMP)Wtsi) results in mice exhibiting orofacial abnormalities, alterations in carpal and rugae structures, hearing impairment and inflammation in the middle ear. In humans it has been hypothesised that the 2-oxoadipate mitochondrial carrier coded by SLC25A21 may be inv...

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Main Authors: Maguire, Simon, Estabel, Jeanne, Ingham, Neil, Pearson, Selina, Ryder, Edward, Carragher, Damian M., Walker, Nicolas, Bussell, James, Chan, Wai-In, Keane, Thomas M., Adams, David J., Scudamore, Cheryl L., Lelliott, Christopher J., Ramírez-Solis, Ramiro, Karp, Natasha A., Steel, Karen P., White, Jacqueline K., Gerdin, Anna-Karin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958370/
https://ncbi.nlm.nih.gov/pubmed/24642684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091807
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