Targeting of Slc25a21 Is Associated with Orofacial Defects and Otitis Media Due to Disrupted Expression of a Neighbouring Gene

Homozygosity for Slc25a21(tm1a(KOMP)Wtsi) results in mice exhibiting orofacial abnormalities, alterations in carpal and rugae structures, hearing impairment and inflammation in the middle ear. In humans it has been hypothesised that the 2-oxoadipate mitochondrial carrier coded by SLC25A21 may be inv...

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Autori principali: Maguire, Simon, Estabel, Jeanne, Ingham, Neil, Pearson, Selina, Ryder, Edward, Carragher, Damian M., Walker, Nicolas, Bussell, James, Chan, Wai-In, Keane, Thomas M., Adams, David J., Scudamore, Cheryl L., Lelliott, Christopher J., Ramírez-Solis, Ramiro, Karp, Natasha A., Steel, Karen P., White, Jacqueline K., Gerdin, Anna-Karin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2014
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3958370/
https://ncbi.nlm.nih.gov/pubmed/24642684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0091807
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