AB053. Role of inflammation in the mucopolysaccharidoses & review of recent therapies

Por Schuchman, Edward H.
Publicado no Ann Transl Med (2015)

The unexpected role of acid sphingomyelinase in cell death and the pathophysiology of common diseases

Por Smith, Eric L., Schuchman, Edward H.
Publicado em 2008

Types A and B Niemann-Pick Disease

Por Schuchman, Edward H., Desnick, Robert J.
Publicado no Mol Genet Metab (2016)

Acid Sphingomyelinase Deficiency Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis in Mice

Por Dhami, Rajwinder, He, Xingxuan, Schuchman, Edward H.
Publicado em 2010

In Vivo Performance of Polymer Nanocarriers Dually-Targeted to Epitopes of the Same or Different Receptors

Por Papademetriou, Iason T., Garnacho, Carmen, Schuchman, Edward H., Muro, Silvia
Publicado em 2013

Recombinant Human Acid Sphingomyelinase as an Adjuvant to Sorafenib Treatment of Experimental Liver Cancer

Por Savić, Radoslav, He, Xingxuan, Fiel, Isabel, Schuchman, Edward H.
Publicado em 2013

Construction of Conditional Acid Ceramidase Knockout Mice and in vivo Effects on Oocyte Development and Fertility

Por Eliyahu, Efrat, Shtraizent, Nataly, Shalgi, Ruth, Schuchman, Edward H.
Publicado em 2012

Sperm Abnormalities in Heterozygous Acid Sphingomyelinase Knockout Mice Reveal a Novel Approach for the Prevention of Genetic Diseases

Por Butler, Avigdor, Gordon, Ronald E., Gatt, Shimon, Schuchman, Edward H.
Publicado em 2007

Brain pathology in Niemann Pick disease type A: Insights from the acid sphingomyelinase knockout mice

Por Ledesma, Maria Dolores, Prinetti, Alessandro, Sonnino, Sandro, Schuchman, Edward H.
Publicado em 2011

Acidic Sphingomyelinase (ASM) Is Necessary for Fas-induced GD3 Ganglioside Accumulation and Efficient Apoptosis of Lymphoid Cells

Por De Maria, Ruggero, Rippo, Maria Rita, Schuchman, Edward H., Testi, Roberto
Publicado em 1998

Intracerebral transplantation of mesenchymal stem cells into acid sphingomyelinase–deficient mice delays the onset of neurological abnormalities and extends their life span

Por Jin, Hee Kyung, Carter, Janet E., Huntley, George W., Schuchman, Edward H.
Publicado em 2002

Characterization of Common SMPD1 Mutations Causing Types A & B Niemann-Pick Disease and Generation of Mutation-Specific Mouse Models

Por Jones, Iwan, He, Xingxuan, Katouzian, Fourogh, Darroch, Peter I., Schuchman, Edward H.
Publicado em 2008

Deregulation of sphingolipid metabolism in Alzheimer's disease

Por He, Xingxuan, Huang, Yu, Li, Bin, Gong, Cheng-Xing, Schuchman, Edward H.
Publicado em 2008

Identification of Cystatin SA as a Novel Inhibitor of Acid Ceramidase

Por Eliyahu, Efrat, Shtraizent, Nataly, He, Xingxuan, Chen, Dafna, Shalgi, Ruth, Schuchman, Edward H.
Publicado em 2011

Comparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptor

Por Papademetriou, Jason, Garnacho, Carmen, Serrano, Daniel, Bhowmick, Tridib, Schuchman, Edward H., Muro, Silvia
Publicado em 2012

Autoproteolytic Cleavage and Activation of Human Acid Ceramidase

Por Shtraizent, Nataly, Eliyahu, Efrat, Park, Jae-Ho, He, Xingxuan, Shalgi, Ruth, Schuchman, Edward H.
Publicado em 2008

Identification and characterization of SMPD1 mutations causing Niemann-Pick types A and B in Spanish Patients

Por Rodríguez-Pascau, Laura, Gort, Laura, Schuchman, Edward H., Vilageliu, Lluïsa, Grinberg, Daniel, Chabás, Amparo
Publicado em 2009

Enhancement of Residual Arylsulfatase B Activity in Feline Mucopolysaccharidosis VI by Thiol-induced Subunit Association

Por Vine, Deborah T., McGovern, Margaret M., Schuchman, Edward H., Haskins, Mark E., Desnick, Robert J.
Publicado em 1982

Reproductive Pathology and Sperm Physiology in Acid Sphingomyelinase-Deficient Mice

Por Butler, Avigdor, He, Xingxuan, Gordon, Ronald E., Wu, Hai-Shan, Gatt, Shimon, Schuchman, Edward H.
Publicado em 2002

Involvement of the Toll-like receptor 4 pathway and use of TNF-α antagonists for treatment of the mucopolysaccharidoses

Por Simonaro, Calogera M., Ge, Yi, Eliyahu, Efrat, He, Xingxuan, Jepsen, Karl J., Schuchman, Edward H.
Publicado em 2009