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Autoproteolytic Cleavage and Activation of Human Acid Ceramidase
Herein we report the mechanism of human acid ceramidase (AC; N-acylsphingosine deacylase) cleavage and activation. A highly purified, recombinant human AC precursor underwent self-cleavage into α and β subunits, similar to other members of the N-terminal nucleophile hydrolase superfamily. This react...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2008
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2431059/ https://ncbi.nlm.nih.gov/pubmed/18281275 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709166200 |
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