Autoproteolytic Cleavage and Activation of Human Acid Ceramidase

Herein we report the mechanism of human acid ceramidase (AC; N-acylsphingosine deacylase) cleavage and activation. A highly purified, recombinant human AC precursor underwent self-cleavage into α and β subunits, similar to other members of the N-terminal nucleophile hydrolase superfamily. This react...

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Autori principali: Shtraizent, Nataly, Eliyahu, Efrat, Park, Jae-Ho, He, Xingxuan, Shalgi, Ruth, Schuchman, Edward H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2008
Soggetti:
Enzyme Catalysis and Regulation
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431059/
https://ncbi.nlm.nih.gov/pubmed/18281275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709166200
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