Autoproteolytic Cleavage and Activation of Human Acid Ceramidase

Herein we report the mechanism of human acid ceramidase (AC; N-acylsphingosine deacylase) cleavage and activation. A highly purified, recombinant human AC precursor underwent self-cleavage into α and β subunits, similar to other members of the N-terminal nucleophile hydrolase superfamily. This react...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Shtraizent, Nataly, Eliyahu, Efrat, Park, Jae-Ho, He, Xingxuan, Shalgi, Ruth, Schuchman, Edward H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2008
Предметы:
Enzyme Catalysis and Regulation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2431059/
https://ncbi.nlm.nih.gov/pubmed/18281275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709166200
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы