Acid Sphingomyelinase Deficiency Attenuates Bleomycin-Induced Lung Inflammation and Fibrosis in Mice

BACKGROUND/AIMS: The sphingomyelin/ceramide signaling pathway is an important component of many cellular processes implicated in the pathogenesis of lung disease. Acid sphingomyelinase (ASM) is a key mediator of this pathway, but its specific role in pulmonary fibrosis has not been previously invest...

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Bibliographic Details
Main Authors: Dhami, Rajwinder, He, Xingxuan, Schuchman, Edward H.
Format: Artigo
Language:Inglês
Published: S. Karger AG 2010
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Original Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3048941/
https://ncbi.nlm.nih.gov/pubmed/21063112
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