Comparative binding, endocytosis, and biodistribution of antibodies and antibody-coated carriers for targeted delivery of lysosomal enzymes to ICAM-1 versus transferrin receptor

Targeting lysosomal enzymes to receptors involved in transport into and across cells holds promise to enhance peripheral and brain delivery of enzyme replacement therapies for lysosomal storage disorders. Receptors being explored include those associated with clathrin-mediated pathways, yet other pa...

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Bibliographic Details
Main Authors: Papademetriou, Jason, Garnacho, Carmen, Serrano, Daniel, Bhowmick, Tridib, Schuchman, Edward H., Muro, Silvia
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3556357/
https://ncbi.nlm.nih.gov/pubmed/22968581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10545-012-9534-6
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