ICAM-1 engagement modulates sphingomyelinase and ceramide, supporting uptake of drug carriers by the vascular endothelium

OBJECTIVE: Engagement of intercellular adhesion molecule 1 (ICAM-1) on endothelial cells (ECs) by ICAM-1-targeted carriers induces cell adhesion molecule (CAM)-mediated endocytosis, providing intra-endothelial delivery of therapeutics. This pathway differs from classical endocytic mechanisms and inv...

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Main Authors: Serrano, Daniel, Bhowmick, Tridib, Chadha, Rishi, Garnacho, Carmen, Muro, Silvia
格式: Artigo
語言:Inglês
出版: 2012
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3331944/
https://ncbi.nlm.nih.gov/pubmed/22328778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.244186
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