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ICAM-1 engagement modulates sphingomyelinase and ceramide, supporting uptake of drug carriers by the vascular endothelium
OBJECTIVE: Engagement of intercellular adhesion molecule 1 (ICAM-1) on endothelial cells (ECs) by ICAM-1-targeted carriers induces cell adhesion molecule (CAM)-mediated endocytosis, providing intra-endothelial delivery of therapeutics. This pathway differs from classical endocytic mechanisms and inv...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3331944/ https://ncbi.nlm.nih.gov/pubmed/22328778 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.111.244186 |
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