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Brain pathology in Niemann Pick disease type A: Insights from the acid sphingomyelinase knockout mice

Severe neurological involvement characterizes Niemann Pick disease (NPD) type A, an inherited disorder caused by loss of function mutations in the gene encoding acid sphingomyelinase (ASM). Mice lacking ASM (ASMko), which mimic NPD type A, have provided important insights into the aberrant brain phe...

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Autors principals: Ledesma, Maria Dolores, Prinetti, Alessandro, Sonnino, Sandro, Schuchman, Edward H.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3059095/
https://ncbi.nlm.nih.gov/pubmed/21214563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2010.07034.x
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