Cellular senescence in cancer treatment: friend or foe?

Por Kahlem, Pascal, Dörken, Bernd, Schmitt, Clemens A.
Publicado em 2004

FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf

Por Bouchard, Caroline, Lee, Soyoung, Paulus-Hock, Viola, Loddenkemper, Christoph, Eilers, Martin, Schmitt, Clemens A.
Publicado em 2007

Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB

Por Rohwer, Nadine, Dame, Christof, Haugstetter, Anja, Wiedenmann, Bertram, Detjen, Katharina, Schmitt, Clemens A., Cramer, Thorsten
Publicado em 2010

INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

Por Schmitt, Clemens A., McCurrach, Mila E., de Stanchina, Elisa, Wallace-Brodeur, Rachel R., Lowe, Scott W.
Publicado em 1999

Neutropenic Sepsis in the ICU: Outcome Predictors in a Two-Phase Model and Microbiology Findings

Por Kruse, Jan M., Jenning, Thomas, Rademacher, Sibylle, Arnold, Renate, Schmitt, Clemens A., Jörres, Achim, Enghard, Philipp, Oppert, Michael
Publicado no Crit Care Res Pract (2016)

A Phase I/II first-line study of R-CHOP plus B-cell receptor/NF-κB-double-targeting to molecularly assess therapy response

Por Denker, Sophy, Bittner, Aitomi, Na, Il-Kang, Kase, Julia, Frick, Mareike, Anagnostopoulos, Ioannis, Hummel, Michael, Schmitt, Clemens A
Publicado no Int J Hematol Oncol (2019)

The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity

Por El-Athman, Rukeia, Genov, Nikolai N., Mazuch, Jeannine, Zhang, Kaiyang, Yu, Yong, Fuhr, Luise, Abreu, Mónica, Li, Yin, Wallach, Thomas, Kramer, Achim, Schmitt, Clemens A., Relógio, Angela
Publicado no PLoS Biol (2017)

Stromal Interferon-γ Signaling and Cross-Presentation Are Required to Eliminate Antigen-Loss Variants of B Cell Lymphomas in Mice

Por Gerbitz, Armin, Sukumar, Madhusudhanan, Helm, Florian, Wilke, Andrea, Friese, Christian, Fahrenwaldt, Cornelia, Lehmann, Frank M., Loddenkemper, Christoph, Kammertoens, Thomas, Mautner, Josef, Schmitt, Clemens A., Blankenstein, Thomas, Bornkamm, Georg W.
Publicado em 2012

Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations

Por Jing, Hua, Kase, Julia, Dörr, Jan R., Milanovic, Maja, Lenze, Dido, Grau, Michael, Beuster, Gregor, Ji, Sujuan, Reimann, Maurice, Lenz, Peter, Hummel, Michael, Dörken, Bernd, Lenz, Georg, Scheidereit, Claus, Schmitt, Clemens A., Lee, Soyoung
Publicado em 2011

Epigenetic Co-Deregulation of EZH2/TET1 is a Senescence-Countering, Actionable Vulnerability in Triple-Negative Breast Cancer

Por Yu, Yong, Qi, Jingjing, Xiong, Jieyi, Jiang, Liping, Cui, Di, He, Junlin, Chen, Ping, Li, Lianjie, Wu, Chenjie, Ma, Tonghui, Shao, Su, Wang, Jianjun, Yu, Dansong, Zhou, Bing, Huang, Dongsheng, Schmitt, Clemens A., Tao, Ran
Publicado no Theranostics (2019)

Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas

Por Shortt, Jake, Martin, Benjamin P., Newbold, Andrea, Hannan, Katherine M., Devlin, Jennifer R., Baker, Adele J., Ralli, Rachael, Cullinane, Carleen, Schmitt, Clemens A., Reimann, Maurice, Hall, Michael N., Wall, Meaghan, Hannan, Ross D., Pearson, Richard B., McArthur, Grant A., Johnstone, Ricky W.
Publicado em 2013

Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma

Por Yu, Yong, Schleich, Kolja, Yue, Bin, Ji, Sujuan, Lohneis, Philipp, Kemper, Kristel, Silvis, Mark R., Qutob, Nouar, van Rooijen, Ellen, Werner-Klein, Melanie, Li, Lianjie, Dhawan, Dhriti, Meierjohann, Svenja, Reimann, Maurice, Elkahloun, Abdel, Treitschke, Steffi, Dörken, Bernd, Speck, Christian, Mallette, Frédérick A., Zon, Leonard I., Holmen, Sheri L., Peeper, Daniel S., Samuels, Yardena, Schmitt, Clemens A., Lee, Soyoung
Publicado no Cancer Cell (2018)

B-cell–specific conditional expression of Myd88(p.L252P) leads to the development of diffuse large B-cell lymphoma in mice

Por Knittel, Gero, Liedgens, Paul, Korovkina, Darya, Seeger, Jens M., Al-Baldawi, Yussor, Al-Maarri, Mona, Fritz, Christian, Vlantis, Katerina, Bezhanova, Svetlana, Scheel, Andreas H., Wolz, Olaf-Oliver, Reimann, Maurice, Möller, Peter, López, Cristina, Schlesner, Matthias, Lohneis, Philipp, Weber, Alexander N. R., Trümper, Lorenz, Staudt, Louis M., Ortmann, Monika, Pasparakis, Manolis, Siebert, Reiner, Schmitt, Clemens A., Klatt, Andreas R., Wunderlich, F. Thomas, Schäfer, Stephan C., Persigehl, Thorsten, Montesinos-Rongen, Manuel, Odenthal, Margarete, Büttner, Reinhard, Frenzel, Lukas P., Kashkar, Hamid, Reinhardt, H. Christian
Publicado no Blood (2016)