FoxO transcription factors suppress Myc-driven lymphomagenesis via direct activation of Arf

FoxO transcription factors play critical roles in cell cycle control and cellular stress responses, and abrogation of FoxO function promotes focus formation by Myc in vitro. Here we show that stable introduction of a dominant-negative FoxO moiety (dnFoxO) into Eμ-myc transgenic hematopoietic stem ce...

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Bibliographic Details
Main Authors: Bouchard, Caroline, Lee, Soyoung, Paulus-Hock, Viola, Loddenkemper, Christoph, Eilers, Martin, Schmitt, Clemens A.
Format: Artigo
Language:Inglês
Published: Cold Spring Harbor Laboratory Press 2007
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2045131/
https://ncbi.nlm.nih.gov/pubmed/17974917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.453107
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