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Myc-induced proliferation and transformation require Akt-mediated phosphorylation of FoxO proteins
Myc synergizes with Ras and PI3-kinase in cell transformation, yet the molecular basis for this behavior is poorly understood. We now show that Myc recruits TFIIH, P-TEFb and Mediator to the cyclin D2 and other target promoters, while the PI3-kinase pathway controls formation of the preinitiation co...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2004
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514943/ https://ncbi.nlm.nih.gov/pubmed/15241468 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600279 |
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