FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function

Exposure of metazoan organisms to hypoxia engages a metabolic switch orchestrated by the hypoxia-inducible factor 1 (HIF-1). HIF-1 mediates induction of glycolysis and active repression of mitochondrial respiration that reduces oxygen consumption and inhibits the production of potentially harmful re...

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Autors principals: Jensen, Kim Steen, Binderup, Tina, Jensen, Klaus Thorleif, Therkelsen, Ib, Borup, Rehannah, Nilsson, Elise, Multhaupt, Hinke, Bouchard, Caroline, Quistorff, Bjørn, Kjær, Andreas, Landberg, Göran, Staller, Peter
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3243591/
https://ncbi.nlm.nih.gov/pubmed/21915097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.323
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