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Cellular senescence in cancer treatment: friend or foe?

Damage to DNA, the prime target of anticancer therapy, triggers programmed cellular responses. In addition to apoptosis, therapy-mediated premature senescence has been identified as another drug-responsive program that impacts the outcome of cancer therapy. Here, we discuss whether induction of sene...

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Detalhes bibliográficos
Main Authors: Kahlem, Pascal, Dörken, Bernd, Schmitt, Clemens A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC311442/
https://ncbi.nlm.nih.gov/pubmed/14722606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420784
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