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Cellular senescence predicts treatment outcome in metastasised colorectal cancer
BACKGROUND: Cellular senescence is a terminal cell-cycle arrest that occurs in response to activated oncogenes and DNA-damaging chemotherapy. Whether cancer cell senescence at diagnosis might be predictive for treatment outcome is unknown. METHODS: A senescence index (SI) was developed and used to r...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939783/ https://ncbi.nlm.nih.gov/pubmed/20628375 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605784 |
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