B-cell–specific conditional expression of Myd88(p.L252P) leads to the development of diffuse large B-cell lymphoma in mice

The adaptor protein MYD88 is critical for relaying activation of Toll-like receptor signaling to NF-κB activation. MYD88 mutations, particularly the p.L265P mutation, have been described in numerous distinct B-cell malignancies, including diffuse large B-cell lymphoma (DLBCL). Twenty-nine percent of...

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Библиографические подробности
Опубликовано в: :Blood
Главные авторы: Knittel, Gero, Liedgens, Paul, Korovkina, Darya, Seeger, Jens M., Al-Baldawi, Yussor, Al-Maarri, Mona, Fritz, Christian, Vlantis, Katerina, Bezhanova, Svetlana, Scheel, Andreas H., Wolz, Olaf-Oliver, Reimann, Maurice, Möller, Peter, López, Cristina, Schlesner, Matthias, Lohneis, Philipp, Weber, Alexander N. R., Trümper, Lorenz, Staudt, Louis M., Ortmann, Monika, Pasparakis, Manolis, Siebert, Reiner, Schmitt, Clemens A., Klatt, Andreas R., Wunderlich, F. Thomas, Schäfer, Stephan C., Persigehl, Thorsten, Montesinos-Rongen, Manuel, Odenthal, Margarete, Büttner, Reinhard, Frenzel, Lukas P., Kashkar, Hamid, Reinhardt, H. Christian
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2016
Предметы:
Lymphoid Neoplasia
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891954/
https://ncbi.nlm.nih.gov/pubmed/27048211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2015-11-684183
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