Hypoxia-Inducible Factor 1α Determines Gastric Cancer Chemosensitivity via Modulation of p53 and NF-κB

BACKGROUND: Reduced chemosensitivity of solid cancer cells represents a pivotal obstacle in clinical oncology. Hence, the molecular characterization of pathways regulating chemosensitivity is a central prerequisite to improve cancer therapy. The hypoxia-inducible factor HIF-1α has been linked to che...

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Detalhes bibliográficos
Main Authors: Rohwer, Nadine, Dame, Christof, Haugstetter, Anja, Wiedenmann, Bertram, Detjen, Katharina, Schmitt, Clemens A., Cramer, Thorsten
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2919384/
https://ncbi.nlm.nih.gov/pubmed/20706634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012038
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