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Mechanism of Hypoxia-Induced NF-κB

NF-κB activation is a critical component in the transcriptional response to hypoxia. However, the underlying mechanisms that control its activity under these conditions are unknown. Here we report that under hypoxic conditions, IκB kinase (IKK) activity is induced through a calcium/calmodulin-depend...

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Detalhes bibliográficos
Main Authors: Culver, Carolyn, Sundqvist, Anders, Mudie, Sharon, Melvin, Andrew, Xirodimas, Dimitris, Rocha, Sonia
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950552/
https://ncbi.nlm.nih.gov/pubmed/20696840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00409-10
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