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Mechanism of Hypoxia-Induced NF-κB

NF-κB activation is a critical component in the transcriptional response to hypoxia. However, the underlying mechanisms that control its activity under these conditions are unknown. Here we report that under hypoxic conditions, IκB kinase (IKK) activity is induced through a calcium/calmodulin-depend...

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Autori principali: Culver, Carolyn, Sundqvist, Anders, Mudie, Sharon, Melvin, Andrew, Xirodimas, Dimitris, Rocha, Sonia
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology (ASM) 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2950552/
https://ncbi.nlm.nih.gov/pubmed/20696840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00409-10
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