Chipping away at diagnostics for neurodegenerative diseases

Por Scherzer, Clemens R.
Publicado em 2009

Network Analysis Identifies SOD2 mRNA as a Potential Biomarker for Parkinson's Disease

Por Santiago, Jose A., Scherzer, Clemens R., Potashkin, Judith A.
Publicado em 2014

A Feed-Forward Circuit of Endogenous PGC-1α and Estrogen Related Receptor α Regulates the Neuronal Electron Transport Chain

Por Bakshi, Rachit, Mittal, Shuchi, Liao, Zhixiang, Scherzer, Clemens R.
Publicado no Parkinsons Dis (2016)

Specific splice variants are associated with Parkinson’s disease

Por Santiago, Jose A., Scherzer, Clemens R., Study, Harvard Biomarker, Potashkin, Judith A.
Publicado em 2013

Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

Por Cho, Hyun-Hee, Cahill, Catherine M., Vanderburg, Charles R., Scherzer, Clemens R., Wang, Bin, Huang, Xudong, Rogers, Jack T.
Publicado em 2010

Defining the contribution of neuroinflammation to Parkinson’s disease in humanized immune system mice

Por Manocha, Gunjan Dhawan, Floden, Angela Marie, Puig, Kendra Lynn, Nagamoto-Combs, Kumi, Scherzer, Clemens R., Combs, Colin Kelly
Publicado no Mol Neurodegener (2017)

Lysosomal Dysfunction Promotes Cleavage and Neurotoxicity of Tau In Vivo

Por Khurana, Vikram, Elson-Schwab, Ilan, Fulga, Tudor A., Sharp, Katherine A., Loewen, Carin A., Mulkearns, Erin, Tyynelä, Jaana, Scherzer, Clemens R., Feany, Mel B.
Publicado em 2010

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

Por Lipinski, Marta M., Zheng, Bin, Lu, Tao, Yan, Zhenyu, Py, Bénédicte F., Ng, Aylwin, Xavier, Ramnik J., Li, Cheng, Yankner, Bruce A., Scherzer, Clemens R., Yuan, Junying
Publicado em 2010

Metallothioneins as dynamic markers for brain disease in lysosomal disorders

Por Cesani, Martina, Cavalca, Eleonora, Macco, Romina, Leoncini, Giuseppe, Terreni, Maria Rosa, Lorioli, Laura, Furlan, Roberto, Comi, Giancarlo, Doglioni, Claudio, Zacchetti, Daniele, Sessa, Maria, Scherzer, Clemens R, Biffi, Alessandra
Publicado no Ann Neurol (2014)

Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse

Por Hu, Yi, Chopra, Vanita, Chopra, Raman, Locascio, Joseph J., Liao, Zhixiang, Ding, Hongliu, Zheng, Bin, Matson, Wayne R., Ferrante, Robert J., Rosas, H. Diana, Hersch, Steven M., Scherzer, Clemens R.
Publicado em 2011

GATA transcription factors directly regulate the Parkinson's disease-linked gene α-synuclein

Por Scherzer, Clemens R., Grass, Jeffrey A., Liao, Zhixiang, Pepivani, Imelda, Zheng, Bin, Eklund, Aron C., Ney, Paul A., Ng, Juliana, McGoldrick, Meghan, Mollenhauer, Brit, Bresnick, Emery H., Schlossmacher, Michael G.
Publicado em 2008

Anti-superoxide dismutase antibodies are associated with survival in patients with sporadic amyotrophic lateral sclerosis

Por van Blitterswijk, Marka, Gulati, Sunita, Smoot, Elizabeth, Jaffa, Matthew, Maher, Nancy, Hyman, Bradley T., Ivinson, Adrian J., Scherzer, Clemens R., Schoenfeld, David A., Cudkowicz, Merit E., Brown, Robert H., Bosco, Daryl A.
Publicado em 2011

MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration

Por Cebrián, Carolina, Zucca, Fabio A., Mauri, Pierluigi, Steinbeck, Julius A., Studer, Lorenz, Scherzer, Clemens R., Kanter, Ellen, Budhu, Sadna, Mandelbaum, Jonathan, Vonsattel, Jean P., Zecca, Luigi, Loike, John D., Sulzer, David
Publicado em 2014

Reduced creatine kinase as a central and peripheral biomarker in Huntington’s disease

Por Kim, Jinho, Amante, Daniel J., Moody, Jennifer P., Edgerly, Christina K., Bordiuk, Olivia L., Smith, Karen, Matson, Samantha A., Matson, Wayne R., Scherzer, Clemens R., Rosas, H. Diana, Hersch, Steven M., Ferrante, Robert J.
Publicado em 2010

Aging, the Central Nervous System, and Mobility in Older Adults: Neural Mechanisms of Mobility Impairment

Por Sorond, Farzaneh A., Cruz-Almeida, Yenisel, Clark, David J., Viswanathan, Anand, Scherzer, Clemens R., De Jager, Philip, Csiszar, Anna, Laurienti, Paul J., Hausdorff, Jeffery M., Chen, Wen G., Ferrucci, Luiggi, Rosano, Caterina, Studenski, Stephanie A., Black, Sandra E., Lipsitz, Lewis A.
Publicado no J Gerontol A Biol Sci Med Sci (2015)

Molecular markers of early Parkinson's disease based on gene expression in blood

Por Scherzer, Clemens R., Eklund, Aron C., Morse, Lee J., Liao, Zhixiang, Locascio, Joseph J., Fefer, Daniel, Schwarzschild, Michael A., Schlossmacher, Michael G., Hauser, Michael A., Vance, Jeffery M., Sudarsky, Lewis R., Standaert, David G., Growdon, John H., Jensen, Roderick V., Gullans, Steven R.
Publicado em 2007

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

Por Hakimi, Mansoureh, Selvanantham, Thirumahal, Swinton, Erika, Padmore, Ruth F., Tong, Youren, Kabbach, Ghassan, Venderova, Katerina, Girardin, Stephen E., Bulman, Dennis E., Scherzer, Clemens R., LaVoie, Matthew J., Gris, Denis, Park, David S., Angel, Jonathan B., Shen, Jie, Philpott, Dana J., Schlossmacher, Michael G.
Publicado em 2011

Identification of genetic modifiers of age-at-onset for familial Parkinson’s disease

Por Hill-Burns, Erin M., Ross, Owen A., Wissemann, William T., Soto-Ortolaza, Alexandra I., Zareparsi, Sepideh, Siuda, Joanna, Lynch, Timothy, Wszolek, Zbigniew K., Silburn, Peter A., Mellick, George D., Ritz, Beate, Scherzer, Clemens R., Zabetian, Cyrus P., Factor, Stewart A., Breheny, Patrick J., Payami, Haydeh
Publicado no Hum Mol Genet (2016)

Seed-competent HMW tau species accumulates in the cerebrospinal fluid of Alzheimer's disease mouse model and human patients

Por Takeda, Shuko, Commins, Caitlin, DeVos, Sarah L., Nobuhara, Chloe K., Wegmann, Susanne, Roe, Allyson D., Costantino, Isabel, Fan, Zhanyun, Nicholls, Samantha B., Sherman, Alexis E., Trisini Lipsanopoulos, Ana T., Scherzer, Clemens R., Carlson, George A., Pitstick, Rose, Peskind, Elaine R., Raskind, Murray A., Li, Ge, Montine, Thomas J., Frosch, Matthew P., Hyman, Bradley T.
Publicado no Ann Neurol (2016)

The NINDS Parkinson’s Disease Biomarkers Program

Por Rosenthal, Liana S., Drake, Daniel, Alcalay, Roy N., Babcock, Debra, Bowman, F. DuBois, Chen-Plotkin, Alice, Dawson, Ted M., Dewey, Richard B., German, Dwight, Huang, Xuemei, Landin, Barry, McAuliffe, Matthew, Petyuk, Vladislav A., Scherzer, Clemens R., St Hillaire-Clarke, Coryse, Sieber, Beth-Anne, Sutherland, Margaret, Tarn, Chi, West, Andrew, Vaillancourt, David, Zhang, Jing, Gwinn, Katrina
Publicado no Mov Disord (2015)