Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

Dysregulation of autophagy, a cellular catabolic mechanism essential for degradation of misfolded proteins, has been implicated in multiple neurodegenerative diseases. However, the mechanisms that lead to the autophagy dysfunction are still not clear. Based on the results of a genome-wide screen, we...

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Bibliographische Detailangaben
Hauptverfasser: Lipinski, Marta M., Zheng, Bin, Lu, Tao, Yan, Zhenyu, Py, Bénédicte F., Ng, Aylwin, Xavier, Ramnik J., Li, Cheng, Yankner, Bruce A., Scherzer, Clemens R., Yuan, Junying
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2010
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2922576/
https://ncbi.nlm.nih.gov/pubmed/20660724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1009485107
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