Selective Translational Control of the Alzheimer Amyloid Precursor Protein Transcript by Iron Regulatory Protein-1

Iron influx increases the translation of the Alzheimer amyloid precursor protein (APP) via an iron-responsive element (IRE) RNA stem loop in its 5′-untranslated region. Equal modulated interaction of the iron regulatory proteins (IRP1 and IRP2) with canonical IREs controls iron-dependent translation...

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Detalhes bibliográficos
Main Authors: Cho, Hyun-Hee, Cahill, Catherine M., Vanderburg, Charles R., Scherzer, Clemens R., Wang, Bin, Huang, Xudong, Rogers, Jack T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2951196/
https://ncbi.nlm.nih.gov/pubmed/20558735
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.149161
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