Iron and the translation of the amyloid precursor protein (APP) and ferritin: riboregulation against neural oxidative damage in Alzheimer’s disease

The essential metals iron, zinc and copper deposit near the Aβ (amyloid β-peptide) plaques in the brain cortex of AD (Alzheimer’s disease) patients. Plaque-associated iron and zinc are in neurotoxic excess at 1 mM concentrations. APP (amyloid precursor protein) is a single transmembrane metalloprote...

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Detalhes bibliográficos
Main Authors: Rogers, Jack, Bush, Ashley, Cho, Hyun-Hee, Smith, Deborah, Thomson, Andrew, Friedlich, Avi, Lahiri, Debomoy K., Leedman, Peter, Huang, Xudong, Cahill, Catherine C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746665/
https://ncbi.nlm.nih.gov/pubmed/19021541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST0361282
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