Novel upregulation of amyloid-β precursor protein (APP) by microRNA-346 via targeting of APP mRNA 5′-untranslated region: Implications in Alzheimer’s disease

In addition to the devastating symptoms of dementia, Alzheimer’s disease (AD) is characterized by accumulation of the processing products of the amyloid-β (Aβ) peptide precursor protein (APP). APP’s non-pathogenic functions include regulating intracellular iron (Fe) homeostasis. MicroRNAs are small...

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Bibliographic Details
Published in:Mol Psychiatry
Main Authors: Long, Justin M., Maloney, Bryan, Rogers, Jack T., Lahiri, Debomoy K.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2018
Subjects:
Immediate Communication
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6514885/
https://ncbi.nlm.nih.gov/pubmed/30470799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-018-0266-3
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