PuF, an antimetastatic and developmental signaling protein, interacts with the Alzheimer’s amyloid-β precursor protein via a tissue-specific proximal regulatory element (PRE)

BACKGROUND: Alzheimer’s disease (AD) is intimately tied to amyloid-β (Aβ) peptide. Extraneuronal brain plaques consisting primarily of Aβ aggregates are a hallmark of AD. Intraneuronal Aβ subunits are strongly implicated in disease progression. Protein sequence mutations of the Aβ precursor protein...

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Autores principales: Lahiri, Debomoy K, Maloney, Bryan, Rogers, Jack T, Ge, Yuan-Wen
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3582491/
https://ncbi.nlm.nih.gov/pubmed/23368879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2164-14-68
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