Novel 5′ Untranslated Region Directed Blockers of Iron-Regulatory Protein-1 Dependent Amyloid Precursor Protein Translation: Implications for Down Syndrome and Alzheimer's Disease

We reported that iron influx drives the translational expression of the neuronal amyloid precursor protein (APP), which has a role in iron efflux. This is via a classic release of repressor interaction of APP mRNA with iron-regulatory protein-1 (IRP1) whereas IRP2 controls the mRNAs encoding the L-...

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Main Authors: Bandyopadhyay, Sanghamitra, Cahill, Catherine, Balleidier, Amelie, Huang, Conan, Lahiri, Debomoy K., Huang, Xudong, Rogers, Jack T.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3729844/
https://ncbi.nlm.nih.gov/pubmed/23935819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0065978
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