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The alpha-synuclein 5(′)untranslated region targeted translation blockers: anti-alpha synuclein efficacy of cardiac glycosides and Posiphen

Increased brain α-synuclein (SNCA) protein expression resulting from gene duplication and triplication can cause a familial form of Parkinson’s disease (PD). Dopaminergic neurons exhibit elevated iron levels that can accelerate toxic SNCA fibril formation. Examinations of human post mortem brain hav...

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Podrobná bibliografie
Vydáno v:J Neural Transm (Vienna)
Hlavní autoři: Rogers, Jack T., Mikkilineni, Sohan, Castelvetri, Ippolita Cantuti, Smith, Deborah H., Huang, Xudong, Bandyopadhyay, Sanghamitra, Cahill, Catherine M., Maccecchini, Maria L., Lahiri, Debomoy K., Greig, Nigel H.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6625511/
https://ncbi.nlm.nih.gov/pubmed/21221670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00702-010-0513-5
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