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Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N(1)-norPosiphen, (+)-N(8)-norPosiphen and (+)-N(1), N(8)-bisnorPosiphen, their inhibition of amyloid precursor protein, α-synuclein synthesis, interleukin-1β, and cholinergic action
A major pathological hallmark of Alzheimer disease (AD) is the appearance in the brain of senile plaques that are primarily composed of aggregated forms of β-amyloid peptide (Aβ) that derive from amyloid precursor protein (APP). Posiphen (1) tartrate is an experimental AD drug in current clinical tr...
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| Publicado no: | Antiinflamm Antiallergy Agents Med Chem |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5214460/ https://ncbi.nlm.nih.gov/pubmed/23360256 |
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