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Synthesis of the Alzheimer drug Posiphen into its primary metabolic products (+)-N(1)-norPosiphen, (+)-N(8)-norPosiphen and (+)-N(1), N(8)-bisnorPosiphen, their inhibition of amyloid precursor protein, α-synuclein synthesis, interleukin-1β, and cholinergic action

A major pathological hallmark of Alzheimer disease (AD) is the appearance in the brain of senile plaques that are primarily composed of aggregated forms of β-amyloid peptide (Aβ) that derive from amyloid precursor protein (APP). Posiphen (1) tartrate is an experimental AD drug in current clinical tr...

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Bibliografske podrobnosti
izdano v:Antiinflamm Antiallergy Agents Med Chem
Main Authors: Yu, Qian-sheng, Reale, Marcella, Kamal, Mohammad A., Holloway, Harold W., Luo, Weiming, Sambamurti, Kumar, Ray, Balmiki, Lahiri, Debomoy K., Rogers, Jack T., Greig, Nigel H.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5214460/
https://ncbi.nlm.nih.gov/pubmed/23360256
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