Manganese causes neurotoxic iron accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin

For more than 150 years it is known that occupational overexposure of manganese (Mn) causes movement disorders resembling Parkinson’s disease (PD) and PD-like syndromes. However, the mechanisms of Mn toxicity are still poorly understood. Here, we demonstrate that Mn dose- and time-dependently blocks...

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Pubblicato in:J Neurochem
Autori principali: Venkataramani, Vivek, Doeppner, Thorsten R., Willkommen, Desiree, Cahill, Catherine M., Xin, Yongjuan, Ye, Guilin, Liu, Yanyan, Southon, Adam, Aron, Allegra, Au-Yeung, Ho Yu, Huang, Xudong, Lahiri, Debomoy K., Wang, Fudi, Bush, Ashley I., Wulf, Gerald G., Ströbel, Philipp, Michalke, Bernhard, Rogers, Jack T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310653/
https://ncbi.nlm.nih.gov/pubmed/30152072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14580
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