Modeling Tuberculosis in Nonhuman Primates

Por Scanga, Charles A., Flynn, JoAnne L.
Publicado no Cold Spring Harb Perspect Med (2014)

TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae

Por Lee, Katherine S., Scanga, Charles A., Bachelder, Eric M., Chen, Quanyi, Snapper, Clifford M.
Publicado em 2007

TLR9 regulates Th1 responses and cooperates with TLR2 in mediating optimal resistance to Mycobacterium tuberculosis

Por Bafica, Andre, Scanga, Charles A., Feng, Carl G., Leifer, Cynthia, Cheever, Allen, Sher, Alan
Publicado em 2005

MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression

Por Scanga, Charles A., Bafica, Andre, Feng, Carl G., Cheever, Allen W., Hieny, Sara, Sher, Alan
Publicado em 2004

Host control of Mycobacterium tuberculosis is regulated by 5-lipoxygenase–dependent lipoxin production

Por Bafica, Andre, Scanga, Charles A., Serhan, Charles, Machado, Fabiana, White, Sandy, Sher, Alan, Aliberti, Julio
Publicado em 2005

Reactivation of Latent Tuberculosis: Variations on the Cornell Murine Model

Por Scanga, Charles A., Mohan, V. P., Joseph, Heather, Yu, Keming, Chan, John, Flynn, JoAnne L.
Publicado em 1999

The Inducible Nitric Oxide Synthase Locus Confers Protection against Aerogenic Challenge of Both Clinical and Laboratory Strains of Mycobacterium tuberculosis in Mice

Por Scanga, Charles A., Mohan, Vellore P., Tanaka, Kathryn, Alland, David, Flynn, JoAnne L., Chan, John
Publicado em 2001

Depletion of Cd4(+) T Cells Causes Reactivation of Murine Persistent Tuberculosis despite Continued Expression of Interferon γ and Nitric Oxide Synthase 2

Por Scanga, Charles A., Mohan, V.P., Yu, Keming, Joseph, Heather, Tanaka, Kathryn, Chan, John, Flynn, JoAnne L.
Publicado em 2000

Characterization of T Cells Specific for CFP-10 and ESAT-6 in Mycobacterium tuberculosis-Infected Mauritian Cynomolgus Macaques

Por Ellis, Amy, Balgeman, Alexis, Rodgers, Mark, Updike, Cassaundra, Tomko, Jaime, Maiello, Pauline, Scanga, Charles A., O'Connor, Shelby L.
Publicado no Infect Immun (2017)

A Tuberculosis Ontology for Host Systems Biology

Por Levine, David M., Dutta, Noton K., Eckels, Josh, Scanga, Charles, Stein, Catherine, Mehra, Smriti, Kaushal, Deepak, Karakousis, Petros C., Salamon, Hugh
Publicado no Tuberculosis (Edinb) (2015)

Rhesus Macaques Are More Susceptible to Progressive Tuberculosis than Cynomolgus Macaques: a Quantitative Comparison

Por Maiello, Pauline, DiFazio, Robert M., Cadena, Anthony M., Rodgers, Mark A., Lin, Philana Ling, Scanga, Charles A., Flynn, JoAnne L.
Publicado no Infect Immun (2018)

A new method to evaluate macaque health using exhaled breath: A case study of M. tuberculosis in a BSL-3 setting

Por Mellors, Theodore R., Blanchet, Lionel, Flynn, JoAnne L., Tomko, Jaime, O’Malley, Melanie, Scanga, Charles A., Lin, Philana L., Hill, Jane E.
Publicado no J Appl Physiol (1985) (2017)

PET imaging of macaques with tuberculosis identifies temporal changes in granuloma glucose metabolism and integrin α4β1-expressing immune cells

Por Mattila, Joshua T., Beaino, Wissam, Maiello, Pauline A., Coleman, M. Teresa, White, Alexander G., Scanga, Charles A., Flynn, JoAnne L., Anderson, Carolyn J.
Publicado no J Immunol (2017)

Analysis of (18)FDG PET/CT Imaging as a Tool for Studying Mycobacterium tuberculosis Infection and Treatment in Non-human Primates

Por White, Alexander G., Maiello, Pauline, Coleman, M. Teresa, Tomko, Jaime A., Frye, L. James, Scanga, Charles A., Lin, Philana Ling, Flynn, JoAnne L.
Publicado no J Vis Exp (2017)

Effects of Tumor Necrosis Factor Alpha on Host Immune Response in Chronic Persistent Tuberculosis: Possible Role for Limiting Pathology

Por Mohan, Vellore P., Scanga, Charles A., Yu, Keming, Scott, Holly M., Tanaka, Kathryn E., Tsang, Enders, Tsai, Ming Chih, Flynn, JoAnne L., Chan, John
Publicado em 2001

Radiologic Responses in Cynomolgus Macaques for Assessing Tuberculosis Chemotherapy Regimens

Por Lin, Philana Ling, Coleman, Teresa, Carney, Jonathan P. J., Lopresti, Brian J., Tomko, Jaime, Fillmore, Dan, Dartois, Veronique, Scanga, Charles, Frye, L. James, Janssen, Christopher, Klein, Edwin, Barry, Clifton E., Flynn, JoAnne L.
Publicado em 2013

Prime-Boost Vaccination with rBCG/rAd35 Enhances CD8(+) Cytolytic T-Cell Responses in Lesions from Mycobacterium Tuberculosis –Infected Primates

Por Rahman, Sayma, Magalhaes, Isabelle, Rahman, Jubayer, Ahmed, Raija K, Sizemore, Donata R, Scanga, Charles A, Weichold, Frank, Verreck, Frank, Kondova, Ivanela, Sadoff, Jerry, Thorstensson, Rigmor, Spångberg, Mats, Svensson, Mattias, Andersson, Jan, Maeurer, Markus, Brighenti, Susanna
Publicado em 2012

rBCG Induces Strong Antigen-Specific T Cell Responses in Rhesus Macaques in a Prime-Boost Setting with an Adenovirus 35 Tuberculosis Vaccine Vector

Por Magalhaes, Isabelle, Sizemore, Donata R., Ahmed, Raija K., Mueller, Stefanie, Wehlin, Lena, Scanga, Charles, Weichold, Frank, Schirru, Giulia, Pau, Maria Grazia, Goudsmit, Jaap, Kühlmann-Berenzon, Sharon, Spångberg, Mats, Andersson, Jan, Gaines, Hans, Thorstensson, Rigmor, Skeiky, Yasir A. W., Sadoff, Jerry, Maeurer, Markus
Publicado em 2008

Mycobacterium tuberculosis Induction of Heme Oxygenase-1 Expression Is Dependent on Oxidative Stress and Reflects Treatment Outcomes

Por Rockwood, Neesha, Costa, Diego L., Amaral, Eduardo P., Du Bruyn, Elsa, Kubler, Andre, Gil-Santana, Leonardo, Fukutani, Kiyoshi F., Scanga, Charles A., Flynn, JoAnne L., Jackson, Sharon H., Wilkinson, Katalin A., Bishai, William R., Sher, Alan, Wilkinson, Robert J., Andrade, Bruno B.
Publicado no Front Immunol (2017)

Aerosol Vaccination with AERAS-402 Elicits Robust Cellular Immune Responses in the Lungs of Rhesus Macaques but Fails to Protect Against High-Dose Mycobacterium tuberculosis Challe...

Por Darrah, Patricia A., Bolton, Diane L., Lackner, Andrew A., Kaushal, Deepak, Aye, Pyone Pyone, Mehra, Smriti, Blanchard, James L., Didier, Peter J., Roy, Chad J., Rao, Srinivas S., Hokey, David A., Scanga, Charles A., Sizemore, Donata R., Sadoff, Jerald C., Roederer, Mario, Seder, Robert A.
Publicado em 2014