rBCG Induces Strong Antigen-Specific T Cell Responses in Rhesus Macaques in a Prime-Boost Setting with an Adenovirus 35 Tuberculosis Vaccine Vector

BACKGROUND: BCG vaccination, combined with adenoviral-delivered boosts, represents a reasonable strategy to augment, broaden and prolong immune protection against tuberculosis (TB). We tested BCG (SSI1331) (in 6 animals, delivered intradermally) and a recombinant (rBCG) AFRO-1 expressing perfringoly...

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Detalhes bibliográficos
Main Authors: Magalhaes, Isabelle, Sizemore, Donata R., Ahmed, Raija K., Mueller, Stefanie, Wehlin, Lena, Scanga, Charles, Weichold, Frank, Schirru, Giulia, Pau, Maria Grazia, Goudsmit, Jaap, Kühlmann-Berenzon, Sharon, Spångberg, Mats, Andersson, Jan, Gaines, Hans, Thorstensson, Rigmor, Skeiky, Yasir A. W., Sadoff, Jerry, Maeurer, Markus
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2582491/
https://ncbi.nlm.nih.gov/pubmed/19023426
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0003790
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