MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression

Mycobacterium tuberculosis possesses agonists for several Toll-like receptors (TLRs), yet mice with single TLR deletions are resistant to acute tuberculosis. MyD88(−/−) mice were used to examine whether TLRs play any role in protection against aerogenic M. tuberculosis H37Rv infection. MyD88(−/−) mi...

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Udgivet i:Infect Immun
Main Authors: Scanga, Charles A., Bafica, Andre, Feng, Carl G., Cheever, Allen W., Hieny, Sara, Sher, Alan
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2004
Fag:
Host Response and Inflammation
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC375220/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15039368/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.72.4.2400-2404.2004
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