MyD88-Deficient Mice Display a Profound Loss in Resistance to Mycobacterium tuberculosis Associated with Partially Impaired Th1 Cytokine and Nitric Oxide Synthase 2 Expression

Mycobacterium tuberculosis possesses agonists for several Toll-like receptors (TLRs), yet mice with single TLR deletions are resistant to acute tuberculosis. MyD88(−/−) mice were used to examine whether TLRs play any role in protection against aerogenic M. tuberculosis H37Rv infection. MyD88(−/−) mi...

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Autores principales: Scanga, Charles A., Bafica, Andre, Feng, Carl G., Cheever, Allen W., Hieny, Sara, Sher, Alan
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2004
Materias:
Host Response and Inflammation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC375220/
https://ncbi.nlm.nih.gov/pubmed/15039368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.4.2400-2404.2004
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