Genomic advances and their impact on clinical trial design

Por Mandrekar, Sumithra J, Sargent, Daniel J
Publicado em 2009

Clinical Trial Designs for Predictive Biomarker Validation: Theoretical Considerations and Practical Challenges

Por Mandrekar, Sumithra J., Sargent, Daniel J.
Publicado em 2009

Clinical Trial Designs for Predictive Biomarker Validation: One Size Does Not Fit All

Por Mandrekar, Sumithra J., Sargent, Daniel J.
Publicado em 2009

Designing a Randomized Clinical Trial to Evaluate Personalized Medicine: A New Approach Based on Risk Prediction

Por Baker, Stuart G., Sargent, Daniel J.
Publicado em 2010

Randomized Phase II Trials: Time for a New Era in Clinical Trial Design

Por Mandrekar, Sumithra J., Sargent, Daniel J.
Publicado em 2010

All-Comers versus Enrichment Design Strategy in Phase II Trials

Por Mandrekar, Sumithra J., Sargent, Daniel J.
Publicado em 2011

Design of clinical trials for biomarker research in oncology

Por Mandrekar, Sumithra J, Sargent, Daniel J
Publicado em 2011

Molecular Pathways: Microsatellite Instability in Colorectal Cancer: Prognostic, Predictive and Therapeutic Implications

Por Sinicrope, Frank A., Sargent, Daniel J.
Publicado em 2012

Clinical implications of microsatellite instability in sporadic colon cancers

Por Sinicrope, Frank A., Sargent, Daniel J.
Publicado em 2009

Predictive biomarker validation in practice: lessons from real trials

Por Mandrekar, Sumithra J, Sargent, Daniel J
Publicado em 2010

Randomized Phase II Cancer Clinical Trials

Por Jung, Sin-Ho, Sargent, Daniel J.
Publicado em 2014

Drug designs fulfilling the requirements of clinical trials aiming at personalizing medicine

Por Mandrekar, Sumithra J., Sargent, Daniel J.
Publicado no Chin Clin Oncol (2014)

Current Issues in Oncology Drug Development, with a Focus on Phase II Trials

Por Sargent, Daniel J., Taylor, Jeremy M.G.
Publicado em 2009

Model-based phase I designs incorporating toxicity and efficacy for single and dual agent drug combinations: Methods and challenges

Por Mandrekar, Sumithra J., Qin, Rui, Sargent, Daniel J.
Publicado em 2010

CAUSAL EFFECTS OF TREATMENTS FOR INFORMATIVE MISSING DATA DUE TO PROGRESSION/DEATH

Por Lee, Keunbaik, Daniels, Michael J., Sargent, Daniel J.
Publicado em 2010

Systemic Therapy for Elderly Patients with Gastrointestinal Cancer

Por Hubbard, Joleen M., Grothey, Axel, Sargent, Daniel J.
Publicado em 2011

A two-stage phase II design with direct assignment option in stage II for initial marker validation

Por An, Ming-Wen, Mandrekar, Sumithra J., Sargent, Daniel J.
Publicado em 2012

A Review of Phase II Trial Designs for Initial Marker Validation

Por Mandrekar, Sumithra J., An, Ming-Wen, Sargent, Daniel J.
Publicado em 2013

Impact of copula directional specification on multi-trial evaluation of surrogate endpoints

Por Renfro, Lindsay A., Shang, Hongwei, Sargent, Daniel J.
Publicado no J Biopharm Stat (2015)

Mining the ACCENT database: a review and update

Por Renfro, Lindsay A., Shi, Qian, Sargent, Daniel J.
Publicado no Chin Clin Oncol (2013)