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All-Comers versus Enrichment Design Strategy in Phase II Trials

Designs for biomarker validation have been proposed and utilized in the Phase III oncology clinical trial setting. Broadly speaking, these designs follow either an enrichment (i.e., targeted) strategy or an all-comers (i.e., unselected) strategy. An enrichment design screens patients for the presenc...

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Detalhes bibliográficos
Main Authors: Mandrekar, Sumithra J., Sargent, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3082391/
https://ncbi.nlm.nih.gov/pubmed/21532916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31820e17cb
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