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Model-based phase I designs incorporating toxicity and efficacy for single and dual agent drug combinations: Methods and challenges
Novel therapies are challenging the standards of drug development. Agents with specific biologic targets, unknown dose-efficacy curves, and limited toxicity mandate novel designs to identify biologically optimal doses. We review two model-based designs that utilize either a proportional odds model o...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2931331/ https://ncbi.nlm.nih.gov/pubmed/20419760 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3706 |
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