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An Adaptive Multi-Stage Phase I Dose-finding Design Incorporating Continuous Efficacy and Toxicity Data from Multiple Treatment Cycles
Phase I designs traditionally use the dose-limiting toxicity (DLT), a binary endpoint from the first treatment cycle, to identify the maximum-tolerated dose (MTD) assuming a monotonically increasing relationship between dose and efficacy. In this article, we establish a general framework for a multi...
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| Publicado en: | J Biopharm Stat |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2018
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6379115/ https://ncbi.nlm.nih.gov/pubmed/30403559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2018.1535497 |
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