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Repeated measures dose-finding design with time trend detection in the presence of correlated toxicity data
BACKGROUND: Phase I trials are designed to determine the safety, tolerability and recommended phase 2 dose of therapeutic agents for subsequent testing. The dose finding paradigm has thus traditionally focused on identifying the maximum tolerable dose of an agent or combination therapy under the ass...
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| Udgivet i: | Clin Trials |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5714674/ https://ncbi.nlm.nih.gov/pubmed/28764555 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774517723829 |
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