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Repeated measures dose-finding design with time trend detection in the presence of correlated toxicity data

BACKGROUND: Phase I trials are designed to determine the safety, tolerability and recommended phase 2 dose of therapeutic agents for subsequent testing. The dose finding paradigm has thus traditionally focused on identifying the maximum tolerable dose of an agent or combination therapy under the ass...

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Detalhes bibliográficos
Publicado no:Clin Trials
Main Authors: Yin, Jun, Paoletti, Xavier, Sargent, Daniel J, Mandrekar, Sumithra J
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714674/
https://ncbi.nlm.nih.gov/pubmed/28764555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774517723829
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