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Dose-finding designs using a novel quasi-continuous endpoint for multiple toxicities
The aim of a phase I oncology trial is to identify a dose with an acceptable safety profile. Most phase I designs use the dose-limiting toxicity, a binary endpoint, to assess the unacceptable level of toxicity. The dose-limiting toxicity might be incomplete for investigating molecularly targeted the...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3813987/ https://ncbi.nlm.nih.gov/pubmed/23335156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5737 |
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