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Dose-finding designs for cumulative toxicities using multiple constraints
This article addresses the concern regarding late-onset dose-limiting toxicities (DLT), moderate toxicities below the threshold of a DLT and cumulative toxicities that may lead to a DLT, which are mostly disregarded or handled in an ad hoc manner when determining the maximum tolerated dose (MTD) in...
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| Publicado no: | Biostatistics |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6296314/ https://ncbi.nlm.nih.gov/pubmed/29140414 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxx059 |
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