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Continual reassessment method with multiple toxicity constraints

This paper addresses the dose-finding problem in cancer trials in which we are concerned with the gradation of severe toxicities that are considered dose limiting. In order to differentiate the tolerance for different toxicity types and grades, we propose a novel extension of the continual reassessm...

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Bibliografische gegevens
Hoofdauteurs: Lee, Shing M., Cheng, Bin, Cheung, Ying Kuen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Oxford University Press 2011
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3062152/
https://ncbi.nlm.nih.gov/pubmed/20876664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxq062
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