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Continual reassessment method with multiple toxicity constraints
This paper addresses the dose-finding problem in cancer trials in which we are concerned with the gradation of severe toxicities that are considered dose limiting. In order to differentiate the tolerance for different toxicity types and grades, we propose a novel extension of the continual reassessm...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3062152/ https://ncbi.nlm.nih.gov/pubmed/20876664 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxq062 |
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