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Model Calibration in the Continual Reassessment Method

BACKGROUND: The continual reassessment method (CRM) is an adaptive model-based design used to estimate the maximum tolerated dose in dose finding clinical trials. A way to evaluate the sensitivity of a given CRM model including the functional form of the dose-toxicity curve, the prior distribution o...

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Autors principals: Lee, Shing M., Cheung, Ying Kuen
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2884971/
https://ncbi.nlm.nih.gov/pubmed/19528132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774509105076
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