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Selection of the initial design for the Two-Stage Continual Reassessment Method
The continual reassessment method (CRM) was proposed in a Bayesian framework whereby the first patient is assigned to the prior guess of the maximum tolerated dose which is usually not the lowest dose level. This assignment may lead to safety concerns in practice because physicians usually prefer no...
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| Publicado no: | J Biopharm Stat |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5383510/ https://ncbi.nlm.nih.gov/pubmed/28300466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2017.1290650 |
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