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Selection of the initial design for the Two-Stage Continual Reassessment Method

The continual reassessment method (CRM) was proposed in a Bayesian framework whereby the first patient is assigned to the prior guess of the maximum tolerated dose which is usually not the lowest dose level. This assignment may lead to safety concerns in practice because physicians usually prefer no...

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Библиографические подробности
Опубликовано в: :J Biopharm Stat
Главные авторы: Jia, Xiaoyu, Ivanova, Anastasia, Lee, Shing M.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5383510/
https://ncbi.nlm.nih.gov/pubmed/28300466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10543406.2017.1290650
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