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Interplay of Priors and Skeletons in Two-Stage Continual Reassessment Method

Model based dose finding designs such as the Continual Reassessment Method (CRM), rely on some basic working model. In the Bayesian setting, these take the form of “guess estimates” of the probabilities of toxicity at each level. In the Likelihood setting, these estimates simply take the form of a m...

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Detalhes bibliográficos
Main Authors: Iasonos, Alexia, O’Quigley, John
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3538840/
https://ncbi.nlm.nih.gov/pubmed/22893483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5559
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