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Adaptive Prior Variance Calibration in the Bayesian Continual Reassessment Method

Use of the Continual Reassessment Method (CRM) and other model-based approaches to design in Phase I clinical trials has increased due to the ability of the CRM to identify the maximum tolerated dose (MTD) better than the 3+3 method. However, the CRM can be sensitive to the variance selected for the...

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Detalhes bibliográficos
Main Authors: Zhang, Jin, Braun, Thomas M., Taylor, Jeremy M.G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3561509/
https://ncbi.nlm.nih.gov/pubmed/22987660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5621
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