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Adaptive Prior Variance Calibration in the Bayesian Continual Reassessment Method
Use of the Continual Reassessment Method (CRM) and other model-based approaches to design in Phase I clinical trials has increased due to the ability of the CRM to identify the maximum tolerated dose (MTD) better than the 3+3 method. However, the CRM can be sensitive to the variance selected for the...
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| Autori principali: | , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3561509/ https://ncbi.nlm.nih.gov/pubmed/22987660 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.5621 |
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