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Dose-finding designs for cumulative toxicities using multiple constraints

This article addresses the concern regarding late-onset dose-limiting toxicities (DLT), moderate toxicities below the threshold of a DLT and cumulative toxicities that may lead to a DLT, which are mostly disregarded or handled in an ad hoc manner when determining the maximum tolerated dose (MTD) in...

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Pubblicato in:Biostatistics
Autori principali: Lee, Shing M, Ursino, Moreno, Cheung, Ying Kuen, Zohar, Sarah
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6296314/
https://ncbi.nlm.nih.gov/pubmed/29140414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/biostatistics/kxx059
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