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Incorporating lower grade toxicity information into dose finding designs

BACKGROUND: Toxicity grades underlie the definition of a dose limiting toxicity (DLT) but in the majority of phase I designs, the information contained in the individual grades is not used. Some authors have argued that it may be more appropriate to consider a polytomous rather than dichotomous resp...

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Hlavní autoři: Iasonos, Alexia, Zohar, Sarah, O’Quigley, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293181/
https://ncbi.nlm.nih.gov/pubmed/21835856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1740774511410732
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