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Adaptive Dose-Finding Studies: A Review of Model-Guided Phase I Clinical Trials

PURPOSE: We provide a comprehensive review of adaptive phase I clinical trials in oncology that used a statistical model to guide dose escalation to identify the maximum-tolerated dose (MTD). We describe the clinical setting, practical implications, and safety of such applications, with the aim of u...

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Detalhes bibliográficos
Main Authors: Iasonos, Alexia, O'Quigley, John
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4121508/
https://ncbi.nlm.nih.gov/pubmed/24982451
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2013.54.6051
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